Center for Structural Biology, National Cancer Institute, Frederick,
\nUSA<\/p>\n
Title: One thousand structures of SARS-CoV-2 proteins, or how the
\nPolish Crystallographic Mafia joined the fight against covid-19<\/p>\n
Date: 29th April 2021 (Thursday!)<\/p>\n
Time: 15:00 pm (Central European Summer Time)<\/p>\n
Host: prof. Joanna Trylska<\/p>\n
Virtual seminar: https:\/\/us02web.zoom.us\/j\/83926960355<\/a> [1<\/a>]<\/p>\n Meeting ID: 839 2696 0355<\/p>\n To subscribe to receive announcements about CeNT UW seminars or to CeNT-UW-Webinars-instruction-for-attendees [3<\/a>]<\/p>\n Abstract:<\/p>\n The response of the scientific community to the COVID-19 pandemic has Centrum Nowych Technologii Uniwersytet Warszawski
\nunsubscribe please click here [2<\/a>]<\/p>\n
\nbeen remarkable, with over 1000 structures related to SARS-CoV-2
\nsubmitted to the Protein Data Bank by mid-April 2021. With structural
\ndata obtained very rapidly by many groups using different techniques and
\nvaried experimental approaches, such efforts may lead to inevitable
\nmistakes, errors, and interpretational problems. To help biomedical
\nresearchers, who may not be experts in structural biology, navigate
\nthrough and absorb the flood of structural information, we have created
\nan online resource, covid19.bioreproducibility.org [4<\/a>], that aggregates
\nexpert-validated information about SARS-CoV-2-related macromolecular
\nmodels. A number of protein complexes with inhibitors, which are most
\nvital for drug design, were found to pose significant problems. Our
\ncritical analysis of a large number of protein structures that are
\npotential or actual targets for drug design, all determined within less
\nthan a year using modern experimental tools, is important not only in a
\ncurrent medical emergency but should be also useful as a paradigm study
\nfor future projects of high interest to biomedical community.<\/p>\n
\nCentre of New Technologies University of Warsaw
\ntel. +48 (22) 55 43600\/603\/647<\/p>\n
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