{"id":2312,"date":"2025-05-14T06:57:01","date_gmt":"2025-05-14T06:57:01","guid":{"rendered":"https:\/\/ptbf.pl\/?p=2312"},"modified":"2025-05-14T06:58:59","modified_gmt":"2025-05-14T06:58:59","slug":"seminarium-112","status":"publish","type":"post","link":"https:\/\/ptbf.pl\/?p=2312","title":{"rendered":"Seminarium"},"content":{"rendered":"
The seminar will be held in a hybrid version.\r\nWe invite you to come in person and meet the Speaker \r\nat the Auditory of the Institute of Physics (left from the main hall).<\/pre>\n
             SEMINARIUM Z FIZYKI BIOLOGICZNEJ I BIOINFORMATYKI\r\n         Instytutu Biochemii i Biofizyki PAN, Instytutu Fizyki PAN,\r\n\t\t\t i Zak\u0142adu Biofizyki UW\r\n\r\n                Wednesday, 21.05.2025, 15:15 (3.15 p.m. CET)\r\n\r\n                               Auditory\r\n              Intitute of Physics, Polish Academy of Sciences\r\n                      Al. Lotnik\u00f3w 32\/46, Warszawa\r\n\r\n                                  and\r\n<\/pre>\n
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    https:\/\/zoom.us\/j\/91976153012?pwd=azNiMWE4UnhPN3lRQlY2UHZHOXVkQT09<\/a>\r\n\r\n\r\n  <\/b> \"Lipid Membrane Texture Induced by Specific Protein Binding and Receptor Clustering:\r\n          Active Roles for Lipids in Cellular Function<\/span>\"<\/b>\r\n\r\n                       Jaros\u0142aw Majewski, Ph. D.\r\n\r\n    Department of Chemical & Biological Engineering at the University of New Mexico, Albuquerque, US.\r\n    Visiting Scientist at Los Alamos National Laboratory, Los Alamos, NM, US.\r\n    Affiliated Professor at the University of Warsaw, Poland.\r\n\r\n\r\n<\/pre>\n
                                       Bogdan Lesyng (UW)\r\n                                       Anna Nied\u017awiecka (IF PAN)\r\n                                       Piotr Zielenkiewicz (IBB)\r\n\r\n\r\nABSTRACT\r\nBiological membranes are complex,\r\nself-organized structures that define boundaries and compartmentalize space in\r\nliving matter. Composed of various lipid and protein molecules, these\r\nresponsive surfaces mediate transmembrane signaling and material transport\r\nwithin the cell and with its environment. It is well known that lipid membrane\r\nproperties change as a function of composition and phase state and that\r\nprotein-lipid interactions can induce changes in the membrane\u2019s properties and\r\nbiochemical response. Here, molecular level changes in lipid organization\r\ninduced by multivalent toxin binding were investigated using grazing incidence\r\nX-ray diffraction. Structural changes to lipid monolayers at the air-water\r\ninterface and bilayers at the solid-water interface were studied before and\r\nafter the specific binding of cholera toxin to membrane-embedded receptors. At\r\nbiologically relevant surface pressures, protein binding perturbed lipid\r\npacking within monolayers and bilayers resulting in topological defects and the\r\nemergence of a new orientationally textured lipid phase. In bilayers this\r\naltered lipid order was transmitted from the receptor-laden exterior membrane leaflet\r\nto the inner leaflet, representing a potential mechanism for lipid-mediated\r\noutside-in signaling by multivalent protein binding. It is further hypothesized\r\nthat cell surface micro-domains exhibiting this type of lipid order may serve\r\nas nucleation sites for vesicle formation in clathrin-independent endocytosis\r\nof cholera toxin.<\/span><\/pre>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\"\"<\/a>
The seminar will be held in a hybrid version. We invite you to come in person and meet the Speaker at the Auditory of the Institute of Physics (left from the main hall). SEMINARIUM Z FIZYKI BIOLOGICZNEJ I BIOINFORMATYKI Instytutu … Czytaj dalej →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[],"class_list":["post-2312","post","type-post","status-publish","format-standard","hentry","category-aktualnosci"],"_links":{"self":[{"href":"https:\/\/ptbf.pl\/index.php?rest_route=\/wp\/v2\/posts\/2312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ptbf.pl\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ptbf.pl\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ptbf.pl\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ptbf.pl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2312"}],"version-history":[{"count":3,"href":"https:\/\/ptbf.pl\/index.php?rest_route=\/wp\/v2\/posts\/2312\/revisions"}],"predecessor-version":[{"id":2315,"href":"https:\/\/ptbf.pl\/index.php?rest_route=\/wp\/v2\/posts\/2312\/revisions\/2315"}],"wp:attachment":[{"href":"https:\/\/ptbf.pl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ptbf.pl\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ptbf.pl\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}