The Centre of New Technologies invites to a webinar by
PROF. ALEXANDER WLODAWER,
Center for Structural Biology, National Cancer Institute, Frederick,
USA
Title: One thousand structures of SARS-CoV-2 proteins, or how the
Polish Crystallographic Mafia joined the fight against covid-19
Date: 29th April 2021 (Thursday!)
Time: 15:00 pm (Central European Summer Time)
Host: prof. Joanna Trylska
Virtual seminar: https://us02web.zoom.us/j/83926960355 [1]
Meeting ID: 839 2696 0355
To subscribe to receive announcements about CeNT UW seminars or to
unsubscribe please click here [2]
CeNT-UW-Webinars-instruction-for-attendees [3]
Abstract:
The response of the scientific community to the COVID-19 pandemic has
been remarkable, with over 1000 structures related to SARS-CoV-2
submitted to the Protein Data Bank by mid-April 2021. With structural
data obtained very rapidly by many groups using different techniques and
varied experimental approaches, such efforts may lead to inevitable
mistakes, errors, and interpretational problems. To help biomedical
researchers, who may not be experts in structural biology, navigate
through and absorb the flood of structural information, we have created
an online resource, covid19.bioreproducibility.org [4], that aggregates
expert-validated information about SARS-CoV-2-related macromolecular
models. A number of protein complexes with inhibitors, which are most
vital for drug design, were found to pose significant problems. Our
critical analysis of a large number of protein structures that are
potential or actual targets for drug design, all determined within less
than a year using modern experimental tools, is important not only in a
current medical emergency but should be also useful as a paradigm study
for future projects of high interest to biomedical community.
Centrum Nowych Technologii Uniwersytet Warszawski
Centre of New Technologies University of Warsaw
tel. +48 (22) 55 43600/603/647
ul. S.Banacha 2c
02-097 Warszawa
