SEMINARIUM Z FIZYKI BIOLOGICZNEJ I BIOINFORMATYKI
Instytutu Biochemii i Biofizyki PAN, Instytutu Fizyki PAN,
i Zakładu Biofizyki UW
Wednesday, 07.05.2025, 15:15 (3.15 p.m. CET)
https://zoom.us/j/91976153012?pwd=azNiMWE4UnhPN3lRQlY2UHZHOXVkQT09
"Protein aggregation in biomolecular condensates:
the case of α-synuclein in host-guest systems"
Dr Wojciech Lipiński
Department of Physical Organic Chemistry
Institute for Molecules and Materials
Radboud University
Nijmegen, The Netherlands
Bogdan Lesyng (UW)
Anna Niedźwiecka (IF PAN)
Piotr Zielenkiewicz (IBB)
ABSTRACT
Protein aggregation, associated with multiple neurodegenerative disorders, has been
a topic of significant scientific interest for decades. However, it is only recently
that the aggregation process has been recognized as being influenced by another
biologically important phenomenon – liquid-liquid phase separation, which underlies
the formation of membraneless organelles. Investigating the role of biomolecular
condensates in protein aggregation is essential for understanding the mechanisms of
amyloid formation and for identifying new strategies for treatment and prevention.
In the talk, I will discuss the key factors through which the physical and chemical
environment of a condensate can influence protein aggregation. I will also focus on
the specific case of α-synuclein (one of the archetypal amyloid-forming proteins),
its aggregation in the presence of model liquid condensates, and the role of
condensate interfaces in this process.
References:
B.S. Visser, W.P. Lipiński, E. Spruijt “The role of biomolecular condensates in
protein aggregation” Nature Reviews Chemistry, 2024,
https://doi.org/10.1038/s41570-024-00635-w
W.P. Lipiński, B.S. Visser, I. Robu, M.A.A. Fakhree, S. Lindhoud, M.M.A.E.
Claessens, E. Spruijt “Biomolecular condensates can both accelerate and suppress
aggregation of α-synuclein” Science Advances, 2022,
https://doi.org/10.1126/sciadv.abq6495
B.S. Visser, M.H.I. van Haren, W.P. Lipiński, K.A. van Leijenhorst-Groener, M.M.A.E.
Claessens, M.V.A. Queirós, C.H.I. Ramos, J. Eeftens, E. Spruijt, “Controlling
interfacial protein adsorption, desorption and aggregation in biomolecular
condensates” bioRxiv preprint, 2024, https://doi.org/10.1101/2024.10.20.619145
