Polskie Towarzystwo Biofizyczne

Więcej szczegółów tutaj: Copernicus

             SEMINARIUM Z FIZYKI BIOLOGICZNEJ I BIOINFORMATYKI
         Instytutu Biochemii i Biofizyki PAN, Instytutu Fizyki PAN,
			 i Zakładu Biofizyki UW

                Wednesday, 19.11.2025, 15:15 (3.15 p.m. CET)                                

    https://zoom.us/j/91976153012?pwd=azNiMWE4UnhPN3lRQlY2UHZHOXVkQT09

                
     "Atomically precise Au/Ag nanoclusters as NIR luminescent markers 
                        for in vivo imaging"

                        
                    Prof. Joanna Olesiak-Bańska

                  Institute of Advanced Materials
            Wroclaw University of Science and Technology
                          www.nona.pwr.edu.pl

                                       Bogdan Lesyng (UW)
                                       Anna Niedźwiecka (IF PAN)
                                       Piotr Zielenkiewicz (IBB)

             SEMINARIUM Z FIZYKI BIOLOGICZNEJ I BIOINFORMATYKI
         Instytutu Biochemii i Biofizyki PAN, Instytutu Fizyki PAN,
			 i Zakładu Biofizyki UW

                Wednesday, 12.11.2025, 15:15 (3.15 p.m. CET)                                

    https://zoom.us/j/91976153012?pwd=azNiMWE4UnhPN3lRQlY2UHZHOXVkQT09

                
"From Viral Protein to Antiviral Lead:
An AI-Assisted In Silico Design Journey"

                        
                    Prof. Nevena Ilieva-Litova

        Institute of Information and Communication Technologies,
                   Department of Scientific Computations
                     Bulgarian Academy of Sciences,             
                          Sofia, Bulgaria  

                                       Bogdan Lesyng (UW)
                                       Anna Niedźwiecka (IF PAN)
                                       Piotr Zielenkiewicz (IBB)


ABSTRACT
The COVID-19 pandemic has underscored the role of structural and
computational biophysics in antiviral discovery. In this talk, I will
present an in silico design workflow that connects viral protein
characterization, molecular dynamics simulations, and AI-based modeling.
We focus on two SARS-CoV-2 proteins – the multifunctional helicase NSP13
and the interferon antagonist ORF6 – as potential drug targets. I will
discuss computationally identified and experimentally confirmed inhibitory
motifs and introduce the concepts of protein aptamers and cyclotides as
promising scaffolds for peptide-based antivirals. Using molecular dynamics
simulations and a convolutional neural network (CNN) trained for
interaction assessment, we have explored the feasibility of grafting viral
peptide motifs onto cyclotide scaffolds. Although this approach is still
under experimental validation, the results demonstrate how AI-enhanced in
silico methods can transform structural insights into rational antiviral
design strategies.

Webinarium Krakowskiego Oddziału Polskiego Towarzystwa Biofizycznego
12 listopada 2025 roku, godz. 18:00
Odbędzie się na platformie ZOOM*:

Tytuł prezentacji:
Interactions that Kill: Applications of Computational Biophysics to Regulated Cell Death in Health and Disease

które wygłosi Pani dr hab. Karolina Mikulska-Ruminska
(Zakład Biofizyki, Instytut Fizyki, Uniwersytet Mikołaja Kopernika w Toruniu)

Abstrakt prezentacji:
Every second, roughly a million of our cells die – some by accident, others through tightly controlled programs. Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation that plays a central role in various diseases, including neurodegenerative disorders (Alzheimer’s, Parkinson’s), asthma, sepsis, cancer, acute brain injury, and inflammatory conditions. To uncover its molecular mechanisms, we employ advanced computational biophysics methods, including molecular dynamics simulations, molecular docking, and elastic network models. These approaches allow us to explain key enzymatic processes driving and suppressing ferroptotic signaling observed in the experimental studies, and to identify potential strategies for therapeutic intervention. Our results provide breakthrough insights into the regulation of ferroptosis and have been published in leading scientific journals (Cell, Nature Chem Biol, PNAS, JACS, and more).

* link do webinarium można uzyskać pisząc na adres: malgorzata.lekka@ifj.edu.pl